Abstract Hyaline fibromatosis syndrome is the current name for clinical manifestations of diseases previously known as “infantile systemic hyalinosis” and “juvenile hyaline fibromatosis”. The authors report representative clinical cases of each one of the above subtypes with emphasis on cutaneous manifestations and difficulties for early diagnosis in this syndrome, essentially of multidisciplinary approach.

Extratos etanólicos de Qualea grandiflora e Copernicia prunifera e extrato hexânico de Dipteryx lacunifera foram avaliados quanto a atividade antibacteriana, utilizando ensaios de difusão a partir de orifício e concentração inibitória mínima (CIM), frente a cepas Gram positivas e Gram-negativas, incluindo espécies multidroga resistentes. O extrato de Q. grandiflora apresentou atividade moderada para as cepas de Staphylococcus epidermidis (CIM = 500 µg/mL) e atividade fraca sobre as demais bactérias Gram-positivas testadas e inativo sobre bactérias Gram-negativas. Os resultados obtidos com S. epidermidis apesar de moderados são importantes, uma vez que este microorganismo é o principal causador de bacteremias e sepse associada com dispositivos médicos implantados. gama-Tocoferol e a mistura de sitosterol e estigmasterol foram isolados do extrato etanólico de raiz de C. prunifera e as estruturas destes compostos foram identificadas com base na análise dos dados espectrais de RMN e comparação com a literatura.

Ethanol extracts of Qualea grandiflora and Copernicia prunifera and hexane extract of Dipteryx lacunifera were evaluated by diffusion in agar and minimum inhibitory concentration (MIC) against Gram-positive and Gram-negative bacteria including multiresistant drug strains. The extract of Q. grandiflora presented moderate activity for Staphylococcus epidermidis (MIC = 500 µg/mL) and weak activity against other Gram-positive strains and inactive for Gram-negative species. The results obtained for S. epidermidis despite being moderate are important because this pathogen is often recovered from bacteremia and sepsis from infections of implanted devices. gamma-Tocopherol and the mixture of sitosterol and stigmasterol were isolated from the ethanol extract of the roots of C. prunifera. The structures of these compounds were identified by NMR spectroscopy and comparison with literature data.

This paper describes total phenolics content and antioxidant activity in the ethanolic extract of leaves, bark and roots of five medicinal plants: Terminalia brasiliensis Camb., Terminalia fagifolia Mart. & Zucc., Copernicia cerifera (Miller) H.E. Moore, Cenostigma macrophyllum Tul. var. acuminata Teles Freire and Qualea grandiflora Mart. The total phenolics content of the plant extracts, determined by the Folin-Ciocalteu method, varied from 250.0 ±8,2 to 763,63 ± 13.03 mg of gallic acid equivalent/g dry EtOH extract. The antioxidant activity of extracts was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay system. Extract of bark from T. brasiliensis, the most active, with an EC50 value of 27.59 ± 0.82 µg/mL, was comparable to rutin (EC50 = 27.80 ± 1.38) and gallic acid (EC50 = 24.27 ± 0.31), used as positive controls. The relationship between total phenolic content and antioxidant activity was positive and significant for T. brasiliensis, C. macrophyllum and C. cerifera.

INTRODUÇÃO: Déficit auditivo tem sido considerado uma das principais manifestações tardias das meningites, sobretudo quando esta ocorre nos dois primeiros anos de vida. No país, poucos são os estudos relatando a evolução de crianças acometidas por meningite e a percentagem e gravidade dos transtornos auditivos e seqüelas neurológicas após a alta hospitalar. OBJETIVO: Caracterizar as principais seqüelas auditivas e neurológicas, delineando o perfil do comprometimento auditivo encontrado cinco anos após a infecção do sistema nervoso central. MÉTODO: Foram incluídas crianças com idade entre 5 e 7 anos, admitidas no Hospital Couto Maia no ano de 1997, e que tiveram diagnóstico de meningite com idade inferior a dois anos. RESULTADOS: 19 crianças passaram pela avaliação neurológica e auditiva. A idade média foi 6 anos e 68,42% eram do sexo masculino. Quanto à etiologia, 52,63% piogênica, 42,1%viral, 5,26% tuberculosa. Alterações auditivas ocorreram em 26,31% da população. CONCLUSÃO: Distúrbios auditivos trazem implicações acadêmicas e sociais às crianças afetadas, especialmente aquelas em idade escolar. Destacamos a necessidade de monitoramento audiológico de todas as crianças com história prévia de meningite.

INTRODUCTION: Auditory deficit has been considered one of the main late manifestations of meningitis, when it occurs during the two first years of life. Few studies have been conducted in Brazil explaining the evolution of children who had meningitis and the percentage, as well the neurological gravity, the auditory problems and sequels after the children left the hospital. OBJECTIVE: To characterize the main auditory and neurological correlation, delineating the profile of the auditory deficits found five years after the central nervous system infection. METHOD: We evaluated children between 5 and 7 years old, admitted in Couto Maia Hospital in the year of 1997, that had been diagnosed with meningitis at an age of two years or below. RESULTS: 19 children passed through the neurological and auditory evaluation. The average age was 6 years and 68.42% were male. In relation to etiology, 52.63% pyogenic, 42.1% viral, 5.26% due to tuberculosis. Auditory alterations had occurred in 26.31% of this population. CONCLUSION: Auditory problems cause academic and social implications in the affected children, especially those of school age. We confirmed the necessity of audiologic following of all children with previous history of meningitis.